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doi: 10.3389/fendo.2023.1332114 Received 02 November 2023 Accepted 04 December 2023 Published 24 January 2024 Volume 14 - 2023 Edited by Stefano Zucchini, IRCCS University Hospital of Bologna Sant Orsola Polyclinic, Italy Reviewed by Cristina Partenope, Azienda Ospedaliero Universitaria Maggiore della Carit, Italy David Ingram, Childrens Mercy Kansas City, United States Updates Copyright 2024 Zaffanello, Pietrobelli, Cavarzere, Guzzo and Antoniazzi

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It is not available as a licensed medicine through the NHS or any regulated UK pharmacy

In the early stages of diabetes, kidney hemodynamic changes, inflammation, and fibrosis occur due to metabolic alterations such as hyperglycemia, systemic hypertension, hyperaminoacidemia, and obesity